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从口服到外用雄激素性秃发治疗增加“局部靶向”新路径_我的网站

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A | 　　随着医学界对雄激素性秃发发病机制认识不断完善，一种新的治疗思路正在临床逐渐形成——既然影响毛囊的重要雄激素代谢主要发生在头皮局部，那么药物是否也可以更加精准地作用于头皮? 　　8月22日，在上海举行的杨国亮皮肤病学大会上，多位毛发医学专家围绕这一问题进行了讨论。　　专家介绍，多数雄激素性秃发患者并不存在明显的全身雄激素升高，其重要发病环节之一，是头皮毛囊局部的睾酮在5α-还原酶作用下转化为双氢睾酮，并持续作用于敏感毛囊。 Fourteen years ago, on 2 December 2011, The Dirty Picture arrived in theatres with an energy that felt bold and unexpected for its time. Films led by women were still uncommon and often followed a familiar formula. But Ekta Kapoor’s vision, paired with Vidya Balan and her fearless performance, shifted the way a heroine could be portrayed and truly celebrated in mainstream cinema. Vidya’s portrayal of Silk became a cultural moment on its own. She brought strength, vulnerability and a raw honesty that made the character unforgettable. The performance earned her the National Award for Best Actress, the Filmfare Best Actress trophy and several international honours, but more than the awards, Silk became a symbol of agency and ambition. The film also changed many conversations. It questioned how women are looked at on screen, explored desire and power from a woman’s point of view and spoke about themes that were rarely addressed in commercial cinema. Even with its unconventional lead, the film became a huge commercial success and proved that stories led by women could attract strong audiences and create impact. Over the years, the film’s influence has only grown. The Dirty Picture encouraged filmmakers to write more layered female characters, gave confidence to women driven stories and played a major part in shifting how female protagonists are treated in Hindi cinema. It also cemented Vidya Balan as one of the most powerful performers of this generation. The themes in the film still feel relevant today. Power, desire, loneliness and identity continue to reflect the experiences of many women in the entertainment world and beyond. And while the line “Entertainment, entertainment, entertainment” is still the most quoted, it is the emotion beneath Silk’s fearless exterior that gives the film its lasting weight. For Vidya Balan, the film marked a turning point. It expanded her range, changed the way audiences saw her and showed the command she brings to every role. Fourteen years later, The Dirty Picture stands not just as a blockbuster but as a landmark that continues to shape how women are portrayed on screen. Also Read: Illuminating Bollywood’s influence on major fashion trends。

B | 　　传统非那雄胺主要采用口服方式，通过抑制5α-还原酶减少双氢睾酮生成。

C | 随着药物递送和制剂技术发展，过去一年，外用非那雄胺喷雾剂在中国批准上市，逐步进入临床应用，使雄激素性秃发的治疗在过去一年里由全身系统性用药进一步延伸到头皮局部用药。

D | 　　这并非简单的“片剂变喷雾”，而是反映了皮肤科治疗逐渐走向精准化和局部化的趋势。　　相关临床研究显示，外用非那雄胺喷雾剂型可以降低头皮局部双氢睾酮水平，并改善部分患者的毛发生长情况，同时对全身激素水平的影响相对较小。　　专家表示，新治疗方式并非意味着传统口服治疗将被取代，而是医生和患者在疗效、安全性和患者个体需求之间增加了一种新的选择。【广告】免责声明：本内容为广告，相关素材由广告主提供，本文仅代表作者个人观点，与本网无关。本网发布目的在于传递更多信息，并不代表本网赞同其观点和对其真实性负责，广告内容仅供读者参考，请自行核实相关内容。